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RNA immunoprecipitation, mRNA stability, and polysome fractioning HuR immunoprecipitation and characterization of cargo RNA was performed as described elsewhere 76,115,116

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First, free carnitine, the cofactor used to transport long-chain and very-long-chain fatty-acids into the mitochondrial matrix, has been shown to be depleted in children with ASD

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Reduced expression of mutant SOD1 in microglia delayed late disease progression and increased survival of SOD1 G37R mice (Boille et al., High calorie diets in ALS A number of studies have tried to correct the energy deficit using metabolic therapies in animal models and patients with ALS, with the hope that an improved metabolism can delay symptoms and extend survival in ALS (Dupuis et al., 2004

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