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In contrast, individuals with SLE have reduced diversity of gut microbiota, with a structural and functional disorder known as dysbiosis ( Firmicutes and Bacteroidetes together account for approximately 98% of the bacterial community, low F/B ratio is linked to gut microbiota dysbiosis, once more pointing to microbial imbalance as being key to SLE pathogenesis ( SLE patients are usually characterized by a condition called leaky gut, which is compromised integrity of the intestinal barrier

It also boosts antioxidant defense system through Nrf-2-mediated antioxidant gene expression and by modulation of peroxisome proliferator activated receptors-regulated genes

Non-clinical PK/PD modeling facilitates the selection of doses for the FIH trial

Hydroperoxide reduction by thioredoxin-specific glutathione peroxidase isoenzymes of Arabidopsis thaliana

Peptides are easily injected into the body and are absorbed directly into the bloodstream where they activate specific intracellular signaling pathways to produce a more rapid response with less side effects