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In response to oxidative agents, inflammation, infections or neurodegeneration, astrocytes undergo profound changes in morphology, gene expression and functiona phenomenon known as astrocyte state transition

10.3390/ph12010026 66 KowdleyK

For example, an acute inflammatory response drives the transcription factor, NFB, to switch melatonin synthesis from pinealocytes to macrophages/microglia and, upon acute inflammatory resolution, back to pinealocytes

Annu Rev Pharmacol Toxicol 46:215234 Drevet JR (2006) The antioxidant glutathione peroxidase family and spermatozoa: a complex story

Disclaimer: The anti-inflammatory properties discussed are based on preclinical studies and anecdotal user feedback

Notably, although numerous studies have reported that redox and performance benefits from antioxidant supplementation, the overall evidence remains mixed