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found significant elevations in glutamate in the occipitoparietal cortex of Al-L-glutamate-treated animals.[30] These observations suggest that the Al-L-glutamate complex can cross the blood-brain barrier (BBB)

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A sustained 14 mmHg reduction in systolic pressure translates to roughly a 40 to 50% reduction in stroke risk and a 20 to 30% reduction in coronary events over the long term

In particular, glutathione and MT conjugates of several metals are formed in the olfactory epithelium and are transported by pinocytosis by the olfactory axons to the brain, thus evading the blood-brain barrier (BBB) [156]

Honors and awards [edit] In 2001, Williams was elected a member of the Institute of Medicine (later the National Academy of Medicine)