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Molecular docking analysis revealed that NE and DA could bind to protein disulfide isomerase (PDI)

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Finally, Hcy levels were not significantly different in homozygous minor TT compared to homozygous wild CC.

Furthermore, 16S rRNA sequencing revealed a rebalancing of the gut microbiota, characterized by a reduced Firmicutes/Bacteroidota ratio, enrichment of beneficial taxa like Bacteroidota and Alloprevotella, suppression of pathobionts such as Desulfovibrionales, and partial restoration of microbial diversity

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