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Photoactivatable analogues that quantitatively cross-link, radiolabel, and activate the insulin receptor

Cosenza-Nashat M, Zhao ML, Suh HS, Morgan J, Natividad R, Morgello S, Lee SC

On the basis of this definition, epigenetics originally referred to all the molecular pathways in which the expression of a genotype is regulated to generate a specific phenotype

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Moreover, the released all-trans retinoic acid, as a differentiation agent, reduce the cancer stem cells stemness and improve the cancer stem cells enriched microenvironment, offering a synergistic effect for enhanced anti-cancer stem cells treatment of photosensitizer in inhibition of in vivo tumor growth and metastasis