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In the pathogenesis of PD, DA oxidation-associated oxidative stress (OS) drives -synuclein aggregation, the primary structural component of Lewy bodies and a pathological hallmark of PD [16]

doi: 10.1021/bi00262a003

This process is amplified by TRPM7 upregulation (35-fold increase in current density) in response to atrial stretch and oxidative stress, directly contributing to electrical conduction heterogeneity in rheumatic heart disease patients [101]

WQ and YT carried out experiments

95 LagunasN.Calmarza-FontI.Diz-ChavesY.Garcia-SeguraL

In fact, in the past twelve months federal spending is barely higher than it was in the final twelve months of the prior administration - despite inflation, aging demographics, higher health care costs, more interest on the national debt, and higher military spending