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Absolute Contraindications include: Personal or family history of medullary thyroid carcinoma (MTC) : The boxed warning specifically contraindicates tirzepatide in patients with a personal or family history of MTC due to the theoretical risk observed in animal studies

For treatment selection, we recommend MRI penis/scrotum before embarking on any surgical approach

Patients with a personal or family history of medullary thyroid carcinoma represent another critical contraindication for tirzepatide-containing formulations

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Significant fertility results can take months

[DOI] [PubMed] [Google Scholar] 20.Honma K., Kohsaka M., Fukuda N., Morita N., Honma S