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Increased oxidative stress and nitrative stress also significantly contribute to the progression of MASLD/MASH

Y., Ramasamy T

In addition, these reactive metabolites can bind to proteins, lipids, or nucleic acids and inhibit the enzymes in the mitochondrial ETC, resulting in oxidative stress, mitochondrial dysfunction, and hepatotoxicity [310, 311]

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This has triggered the evolution of resistance mechanisms whereby the water-soluble toxic form of mercury, the Hg 2+ cation (either aquated or coordinated to ligands such as chloride), is reduced back to the mono-atomic elemental form, the atoms of which are volatile and can be eliminated from the organism back into the environment [87]

[DOI] [PubMed] [Google Scholar] 296.Raaschou-Nielsen O