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Patients who develop symptoms of unexplained hyperammonemic encephalopathy while receiving valproate therapy should receive prompt treatment (including discontinuation of valproate therapy) and be evaluated for underlying urea cycle disorders (see Contraindications and Hyperammonemia and Encephalopathy Associated with Concomitant Topiramate Use as follows)

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It supports beneficial levels of active glutathione in the bloodstream and improves the ratio of active glutathione to oxidized glutathione in a way that other approaches cant.*

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