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doi: 10.3390/biom11071030

10.3389/fphys.2013.00185 Front

It is important to clarify that, whereas population-level PRS models require formal effect-size modeling, linkage disequilibrium correction, ancestry calibration, and validation across large cohorts, the score used in this workflow is a functional polygenic score (PRS-F) designed for mechanistic, individual-level interpretation rather than for epidemiological prediction

doi:10.1007/BF00762777

Extracts of the medium were incubated at 80 C for at least 15 min before being centrifuged at 15,000 g for 20 min

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