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In other words, target selection should consider their resistance liability, defined as the likelihood that genetic or phenotypic adaptations will reduce drug efficacy under selective pressure

These enzymes may elicit anti-neoplastic effects

As for the culture environment in vitro, where only AML cells are present, orid-liposome-MAL can non-competitively enter all AML cells, causing REDOX imbalance and exerting its anti-tumor effects

Sotgiu et al., 2015)

S2CID 23988054

The protocol for immobilization of GST-SPINK3 to glutathioneagarose beads was modified from previously reported protocols by using an alternative bifunctional cross-linker (dithiobis(succinimidyl propionate)) in a very simple procedure and by using simple buffers under physiological conditions