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doi: 10.3390/ijms21072649

The cerebrovasculature is a very bioenergetically active tissue with capillary endothelial cells having been shown to possess five times more mitochondria than muscle cells (Oldendorf and Brown, 1975) and transport 10 times their weight in glucose each minute across the BBB, along with accomplishing other energetically costly cellular processes (Cunnane et al., 2011)

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Symptoms and complications include hypoketotic hypoglycaemia (especially in response to prolonged fasting), which in its turn may lead to lethargy, convulsions, vomiting, coma and even death