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Author Contributions RJW: Conceptualization (lead), Methodology (lead), Investigation (lead), Formal analysis (lead), Funding acquisition (equal), Writing-original draft (lead)

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Untreated B12 deficiency causes peripheral neuropathy (tingling, numbness, balance issues) and, in severe cases, cognitive decline

A review of the treatment for increasing NAD + was conducted in this section, with a summary of their biological effects and mechanisms respectively presented in Tables 1, 2, 3 and 4

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