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Regarding the glutamate metabolic pathways, they also found some limited evidence of altered expression of the excitatory amino acid transporter-2 (synaptic re-uptake), glutamine synthetase (glial change of glutamate to glutamine), and glutaminase (presynaptic change from glutamine to glutamate prior to vesicular re-packaging)

doi:10.3390/nu15040986

T-cell immunobiology and cytokine storm of COVID-19

7 Future research directions Despite remarkable advances in understanding the reproductive toxicity of environmental endocrine disruptors, fundamental knowledge gaps continue to impede comprehensive risk assessment and effective intervention development

With respect to the polyamines, spermidine is the only molecule in this family that has been shown to exhibit these effects