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In particular, two RCTs showed the efficacy of PGB compared to placebo on pain and related symptoms in adults [21, 22] and one study in adolescents with FM [20] failed to show a significant improvement in mean pain score

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Modeling rett syndrome using TALEN-edited MECP2 mutant cynomolgus monkeys

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En todos estos estudios el grupo placebo no corresponde a no tratamiento, sino a un grupo en el que no se utiliz tratamiento farmacolgico adicional a los cambios en el estilo de vida