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While these findings have generated significant interest, human studies remain limited, making it difficult to draw definitive conclusions about its clinical benefits

When joint discomfort occurs after starting B12, it is typically coincidental or related to other factors such as excipients in formulations, injection-site effects, pre-existing musculoskeletal conditions, or rare hypersensitivity reactions rather than a direct effect of the vitamin itself

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In the majority of cases, people with elevated B12 feel completely normal, and the finding only appears on routine blood work

And they've modeled this out like a steroid hormone

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