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It was observed that in a subgroup of FM patients, treatment with N-methyl-D-aspartate (NMDA) receptor antagonists improved symptoms and pain perception [22]

Glutathione is a tripeptide made up of three components, which are glycine, cysteine, and glutamic acid

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In triple-negative breast cancer, for example, IFN--mediated downregulation of SLC7A11 not only potentiates ferroptosis but also enhances CD8+ T cell infiltration, creating a positive feedback loop that is absent in SLC7A11-low colorectal cancers, highlighting the need for tumor-specific biomarker stratification (190).First, IFN directly stimulates the expression and activity of ACSL4, remodeling the lipid composition of cancer cell membranes by increasing polyunsaturated phospholipid (PUFAPL) content, thereby rendering cells more susceptible to ferroptosis (189)

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