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Although hypericin has been traditionally employed for various therapeutic purposes, a comprehensive assessment of its toxicological properties is essential to ensure safe administration.34 Hypericin is characterized by relatively low acute toxicity, with mild and reversible symptoms typically observed following single high-dose exposure

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A decrease in viability can be observed in 2 cell types, with fibroblasts reacting more sensitive than epithelial cells

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Protocols for neuroprotection use 0.25 to 0.5 mg daily subcutaneously or orally

[DOI] [PMC free article] [PubMed] [Google Scholar] 23.Vitvitsky V., Dayal S., Stabler S., Zhou Y., Wang H., Lentz S.R., Banerjee R