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It is not understood if the interaction of PML-II with the INM is direct, involves adaptor proteins or post-translational modifications (Figure 1) ( RNA-mediated silencing of PML-II in U2OS cells did not significantly affect total nLD abundance and size ( High resolution imaging of immunostained LAPS in U2OS cell revealed that CCT and PML occupy different regions of the LAPS and have minimal overlap

So far, it seems to be a good choice

Cluster 6 contained proteins enriched in sEVs and high-density sEVs, and was associated with the cytosol, proteasome, and nucleoplasm

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Prog Lipid Res 49:6175

doi: 10.1093/cercor/bhx005