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Carboxylic acid and hydroxy reactive moieties may also be blocked with hydrolytically removable protective groups such as the benzyl group, while amine groups capable of hydrogen bonding with acids may be blocked with base labile groups such as Fmoc

This creates a washout consideration: if a study requires crossover design or rapid cessation, tesofensine's long half-life delays pharmacological clearance

(2) Treated the two sibling-controlled studies as merely two among many rather than recognizing their superior design

10.1016/j.scr.2016.03.009 11 ChenY

Under basal or lipotoxic conditions, G9a represses autophagy by enriching H3K9me2 at the promoters of LC3B, WIPI1 , and DOR , thereby silencing their transcription and reducing their autophagic activity

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