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Although a higher lipophilicity should lead to an enhanced cellular uptake, as Pt(IV) complexes (unlike Pt(II) complexes) enter cells solely by passive diffusion, a lack of correlation between log P values and cellular Pt levels is not unprecedented 31,32

290 A phase I/II trial is currently underway to evaluate the efficacy of JHU-083 in advanced solid tumors (NCT04471415) (Table 1)

Deng, and Xuzhou Medical University Youth Science and Technology Innovation Team Program (No

IV therapy delivers glutathione directly into your bloodstream, ensuring that 100% of the antioxidant is absorbed for maximum benefit

Comparison of four basic models of indirect pharmacodynamic responses, J

Oxidative stress and chronic inflammation in osteoarthritis: Can NRF2 counteract these partners in crime