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In addition, heterozygous GPx1 +/ mice had augmented endothelial dysfunction, characterized by a decrease in acetylcholine-mediated vasodilator responses, in carotid arteries following exposure to angiotensin II, a known activator of NADPH-oxidase-dependent ROS generation [73]

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10.1016/S0962-8924(98)01359-2 Trends Cell Biol

Liver metabolism shows no accumulation after seven consecutive days of dosing in animal models, suggesting the peptide does not build up with frequent administration