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In conclusion, a therapeutic approach to IVD degeneration involving enhanced tissue repair by exogenous growth factors may be clinically important, but more research is needed to address the efficacy, duration of action, safety, and adverse effects of the growth factors administered in vivo

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Bowie, A

The amount of HGF inhibitor that is administered may be in the range of from about 0.1 to about 1 ,000 mg/kg, an preferably in the range of from about 1 to about l OOmg/kg, although as one of skill in the art will recognize, the precise amount may vary depending on one or more attributes of the drug recipient, including but not limited to: weight, overall health, gender, age, nationality, genetic history, other conditions being treated, etc., and larger or smaller doses are within the practice of this invention