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10.1016/j.tiv.2013.06.019 Toxicol

67 In our small series, PERM is highly responsive to immunotherapies, especially if started early

[DOI] [PubMed] [Google Scholar] 244

Based on known mechanisms, TrxR1/Gsr-null hepatocytes could therefore neither acquire reduced Cys from the blood plasma nor by disulfide reduction in the cystosol

46,47 It directly scavenges ROS and upregulates the expression of antioxidant enzymes such as superoxide dismutase (SOD) and glutathione peroxidase (GPX), reducing oxidative damage and SASP accumulation in immune cells