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Polycyclic aromatic hydrocarbons (PAHs) found in cigarette smoke, for example, have been shown to decrease the activity of P450 enzymes, leading to a decrease in SAMe production and impaired DNA methylation

It is known to suppress the activity of several important genes involved in the progression of MASLD, including hepatocyte nuclear factor 4 (HNF4), peroxisome proliferator-activated receptor (PPAR), and SIRT1 [297]

GSTK1 Glutathione S-transferase kappa 1 (GSTK1) is an enzyme that in humans is encoded by the GSTK1 gene which is located on chromosome seven

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All antibodies used for immunohistochemistry (IHC) are presented in Supplementary Table 6

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