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This increase was associated with enhanced trimethylation of histone H3 at lysine 4 (H3K4me3) at the CCR2 promoter in the NAc ( in vivo , the long-term effects, and the possible side effects

May slow down the aging process

By inhibiting autophagy and inducing mitochondrial ROS, TMAO activates NLRP3 inflammasome, leading to the release and pyroptosis of IL-1/IL-18 dependent on caspase-1 in colon epithelium, which is a hallmark of IBD severity

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The apobec-1 editing complex is expressed in the intestine and edits a specific cytidine to an uracil in the apo B mRNA in the intestine creating a stop codon that results in the cessation of protein translation and a shorter Apo B (Apo B-48)

However, research suggests that these side effects are uncommon