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Description
The honest answer, based on the available research, is that the effect is real and directionally consistent with the physiology, but modest under ordinary circumstances not the dramatic swing implied by many unsourced blog claims

F.MullerW

A negative test will not change the clinical plan, because 26% of patients who met the strict NIDDK criteria for IC/BPS had a negative test

Check thyroid, iron, vitamin D, zinc

Diabetes 59 , 161171 (2010)

Hinkel J, Schmitt J, Wurm M, et al