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In this context, by potentially interfering with the transcription of steroidogenic genes including 3-HSD and 17-HSD , ATZ may have an anti-androgenic impact 39

Calcium-dependent membrane damage accelerates necrosis

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Treatment includes corticosteroids, immunoglobulins, immunosuppressants, plasma exchange, and rituximab to rapidly minimize cerebellar ataxia in the short term, with long-term maintenance therapy to prevent relapse

[DOI] [PMC free article] [PubMed] [Google Scholar] 17.Shimada A, Castrillon E, Baad-Hansen L, Ghafouri B, Gerdle B, Ernberg M, et al

There was also a decrease in the markers for oxidative stress at six months as indicated through an improvement in the oxidized (GSSG) to reduced (GSH) glutathione ratio in whole blood, in conjunction with favorable increases in natural killer cell cytotoxicity