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Elevated levels of homocysteine are correlated with several pathologies, and are recognized as an initiating factor for arteriosclerosis of coronary, cerebral and peripheral vessels (Boushey et al., 1995

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doi: 10.1016/j.cmet.2015.02.003 109 ZhangJRudemillerNPPatelMBKarlovichNSWuMMcDonoughAAet al

Yet, when administered, Lactobacillaceae and Bifidobacteriaceae taxa that have the genetic and biochemical potential 34 might produce riboflavin in situ as a (temporary) part of the gut (and other) microbiota, resulting in altered epithelial morphology as shown in a murine in vivo model 179

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