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With the deepening of the research on CDI therapies, the development of bioactive molecules and vaccines continues to provide new aspects for the disease prevention and treatment (Kordus et al., 2021

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Hberle J, Pauli S, Schmidt E, Schulze-Eilfing B, Berning C, Koch HG (2003) Mild citrullinemia in Caucasians is an allelic variant of argininosuccinate synthetase deficiency (citrullinemia type 1)

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Moreover, increased ACE2 expression in mice has been associated with enhanced sympathetic activity [96, 97] and reduced tryptophan uptake [98], which may increase susceptibility to the effects of stressful conditions [99]

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