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demonstrated that the endogenous tetrapeptide N-acetyl-serinyl-aspartyl-lysinyl-proline (AcSDKP) has the ability to restore protein levels of SIRT3, CPT1a, and PGC1 and inhibit the expression of GLUT1, PKM2, and PDK4

Unlike other gaseous signaling molecules such as carbon monoxide, nitric oxide (NO), and H 2 sulfide (H 2 S), H 2 has an excellent safety profile and exerts protective effects without toxicity risks, even at high concentrations [15, 16]

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These food-grade enzymes can also be used together to enhance the release of encrypted peptides from parental proteins

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