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The therapeutic mechanisms of these natural products have been summarised, including direct regulation of McSCs, melanin production, melanin transport, and related signalling pathways such as the cAMP/PKA and MAPK signalling pathways

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Cozzolino M, Vitagliano A

Both ghrelin and GHS-R1a have corresponding widespread tissue expression (331)

[DOI] [PMC free article] [PubMed] [Google Scholar] 6.Meredith MJ, Reed DJ

Thus, excessive CB1 activation with exogenous THC may lead to NMDAR hypofunction which in turn downregulates genes involved in synthesis, recycling and utilization of GSH in developing neurons, promoting oxidative stress