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Kaempferol exhibits diverse pharmacological properties, including anticancer [56], anti-inflammatory [57], antioxidant [58], and anti-thrombotic activities and pleiotropic cardiovascular protective effects [59]

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The present application is dedicated to the characterization of different compositions of ML-I loaded TSL and USL, their evaluation for stability and triggered release, and the in vitro cellular handling and efficacy of the most promising formulations by live cell-imaging

This mechanism was further validated in CRISPR-edited iPSCs [135]

Abbreviations ALI: Acute Lung Injury ECM: Extracellular Matrix FN1: Fibronectin 1 GSH: Glutathione H&E: Hematoxylin and Eosin Hg: Mercury HIF1: Hypoxia-Inducible Factor 1 MDA: Malondialdehyde MMP: Matrix Metalloproteinase MPO: Myeloperoxidase NAC: N-Acetylcysteine NO: Nitric Oxide NOS: Nitric Oxide Synthase qRT-PCR: Quantitative Real-Time Polymerase Chain Reaction ROS: Reactive Oxygen Species SOD: Superoxide Dismutase TIMP: Tissue Inhibitor of Metalloproteinases References Da Silva RF, Borges Cdos S, Villela ESP, Missassi G, Kiguti LR, Pupo AS, Barbosa Junior F, Anselmo-Franci JA, Kempinas Wde G