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3.1.3.4 The regulation of bone metabolism via inflammatory factors Under inflammatory conditions, the levels of pro-inflammatory factors such as TNF- and interleukin-1 beta (IL-1) are significantly elevated
doi: 10.1073/pnas.2101592118 128 ChengYLinLLiXLuAHouCWuQet al

doi:10.1080/10284150500162937 Abadi S, Papoushek C, Evans MF

That is because the underlying issue is instability

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These typically resolve as the body adapts
