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doi: 10.1007/S12264-013-1423-Y

Typically, the concentration of carnitine in plasma is in the low M range (~4060), while tissue concentrations (taken here to approximate cytoplasmic concentrations) are in the low mM range (~15 mM) 26,27

(121944) side effects Hypotension, bradycardia (especially if given too rapidly or to patients with cardiac comorbidity)

Metabolic Flexibility and Acetyl-CoA/CoA Ratio The presence of free carnitine within the mitochondria allows for the generation of acetyl-l-carnitine (ALC) necessary for the reduction of acetyl-CoA and the generation of free CoA which is needed for glycolysis to proceed

Inside cells, carnitine's established biological role is to carry long-chain fatty acids across the membrane into the mitochondria a process often called the carnitine shuttle