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Metformin lowers Ser-129 phosphorylated -synuclein levels via mTOR-dependent protein phosphatase 2A activation

Here, we found that the neuronal conditional-knockout (KO) of glutamyl-cysteine-ligase catalytic-subunit (GCLC), a rate-limiting enzyme for glutathione synthesis, induced brain atrophy accompanied by neuronal loss and neuroinflammation

Individual responses vary based on baseline health and lifestyle factors

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Beneficial Effects of Epigallocatechin-3-O-Gallate, Chlorogenic Acid, Resveratrol, and Curcumin on Neurodegenerative Diseases