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In contrast to mice and adult humans, the alternative pathway is the predominant biosynthetic pathway in human neonates, as evidenced by low to undetectable CYP7A1 expression in newborns and the finding of severe cholestatic liver disease in infants with inherited oxysterol 7-hydroxylase ( CYP7B1 ) gene defects

Hesperetin protects against palmitate-induced cellular toxicity via induction of GRP78 in hepatocytes

doi: 10.1016/j.jep.2023.117689 83 WangXLiYXieHDaiZMaLZhuXet al

Place in Therapy Phenytoin has long been a first-line AED for primary generalized convulsive and partial seizures

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A sensitive and selective fluorescent thiol probe in water based on the conjugate 1, 4addition of thiols to , unsaturated ketones