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(c) transferring the organic phase directly into the aqueous component, while homogenizing the combination with a high performance mixing apparatus, in particular a high-shear mixer
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The overstimulation of neurons activates microglia, the resident immune cells of the brain, which release proinflammatory cytokines, such as TNF- and IL-1, as well as ROS (Figure 1)

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The first peptide drug insulin was isolated in 1921 and became commercially available in 1923
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