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Severe GI reactions (peptic ulcer, GI bleeding, and GI perforation) occurred in 0.4% to 4.6% of patients without a history of a peptic ulcer or bleed and in 2.1% to 15.4% of patients with a history of a peptic ulcer or bleed

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The two-way ANOVA was applied to the log of the ARB fraction as the dependent variable

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New medications: These can bring on changesfor instance, steroids, antidepressants, or antihistamines can influence fluid balance or appetite

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High serum concentrations of vitamin B12 may be encountered while the clinical picture suggests B12 deficiency

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Mood Changes: Increased irritability, depression, or anxiety

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