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Encapsulation within CS-NPs confers multiple advantages, including improved aqueous solubility, protection from enzymatic degradation and pH variations in the GI tract, controlled and sustained release of phytoconstituents, and enhanced intestinal absorption through prolonged GI residence mediated by mucoadhesive properties, collectively augmenting the oral bioavailability and bioactivity (96)

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The second enzyme that can contribute to the production of polysulfides is CARS mentioned above in the persulfide section

doi:10.1158/0008-5472.CAN-05-0808 Coriat R, Nicco C, Chreau C et al (2012) Sorafenib-induced hepatocellular carcinoma cell death depends on reactive oxygen species production in vitro and in vivo

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