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As a newly discovered form of cell death, the precise mechanisms that underlie cuproptosis are poorly understood, although the lipoic acid pathway has been shown to play a key role in mediating cuproptosis

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Nevertheless, a major concern arises from the direct injection of the mixture of IL-12 and aCTLA-4 (IL/aC), which may result in uncontrolled activation of immune cells and an IL-12-induced cytokine storm 23

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Table 1 summarises the main hormonal alterations in endometriosis

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Diabetes (2020) 69:272034

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