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Mitochondrial and energy-pathway models: Exploring how ERR activation correlates with mitochondrial-associated transcriptional signatures and cellular energy-demand responses in controlled experimental conditions

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Given that both diet composition and adiposity can each substantially impact the gut microflora in obese mice 24 , we conducted a secondary endpoint study using animals given the same series of diets to test the hypothesis that NNMTi treatment combined with LD, but not LD alone, shifts the cecal microbiome profile of obese animals to be similar to age-matched LD controls that were never given a high-fat diet

[DOI] [PMC free article] [PubMed] [Google Scholar] Szab S