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Second, the enzyme Glo2 can catalyze the conversion of LGSH to d-lactate and regenerate reduced glutathione such that methylglyoxal detoxification does not net consume reduced glutathione

This promotes the degradation of SLC7A11, further intensifying oxidative stress and subsequent ferroptosis in CRC cells

Advise female patients of reproductive potential to use effective contraception during treatment with JUXTAPID and for two weeks after the final dose

PMID: 309 GaoJAksoyBADogrusozUDresdnerGGrossBSumerSOet al

PubMed PMID: 31173262 Kim DH, Kim MJ, Kim NY, Lee S, Byun JK, Yun JW et al (2022) DN200434, an orally available inverse agonist of estrogen-related receptor , induces ferroptosis in sorafenib-resistant hepatocellular carcinoma

Weiner, M., Sarantopoulos, C