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Central auditory dysfunction in older persons with memory impairment or Alzheimer dementia

Flagellin is a natural ligand of TLR5, specifically the highly conserved D1 domain at its N-terminus

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8 The body requires a delicate balance between production and detoxification/transport of harmful reactive species and protein adducts, and when these defenses are overwhelmed at hepatotoxic doses of APAP, the glucoronidation and sulfonation pathways become saturated, pushing the majority of APAP to be metabolized to NAPQI by the CYP 2E1 pathway and resulting in GSH depletion and build-up of toxic NAPQI

Tupova, L
