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While antioxidants such as vitamins C and E, melatonin, N-acetylcysteine, and mitochondrial-targeted compounds have shown beneficial effects in experimental models, their clinical efficacy remains inconsistent or inconclusive in humans

Yoneyama et al

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23 Participants also had their weight (kg

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Previous studies elucidate that SLC25A39 regulates mitochondrial glutathione homeostasis by binding GSH-sensitive [2Fe-2S] clusters via cysteines in a unique ring structure, thereby protecting mitochondria from iron overload and preserving function 17