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10.3389/fonc.2022.693395 63 LiZ.-j.DaiH.-q.HuangX.-w.FengJ.DengJ.-h.WangZ.-x.et al (2020b)

Studies have observed decreased cyclooxygenase-2 (COX-2) gene expression, reduced myeloperoxidase activity, and lower levels of pro-inflammatory cytokines including interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-)

This pathological mechanism involves the following sequential steps: 1) activation of the redox-sensitive metalloproteinase-9 (MMP9) by a redox dysregulation

Other studies in animals have provided strong evidence of the potential benefits of NAC on heart disease

Ochoa-Callejero and colleagues exemplified that CGRP serum level is reduced in Covid-19 due to immune deregulation [74]

Elevated blood sugar Since cortisone is involved in maintaining normal levels of glucose (sugar) in the blood, long-term use may lead to elevated blood sugar or even diabetes