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On one hand, caspase-1 cleaves and converts pro-IL-1 and pro-IL-18 into their active forms

A detailed analysis of the antiobesity action of fenfluramine disclosed that it directly activates hypothalamic POMC neurons through 5-hydroxytryptamine 2C (5-HT2C) receptors that are expressed on a majority of these cells [80]

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This specific and sensitive detection method for assessing the methylation status of the GSTP1 gene shows great promise as a rapid screening test to determine risk factors through a simple blood test [25]

doi: 10.1002/eji.201747263 112 O'ConnorRSHaoXShenKBashourKAkimovaTHancockWWet al

3.2.1 PINK1/Parkin mediated mitophagy The pathway consisting of PINK1 and Parkin is a key participant in mitophagy, as well as the most common and classical pathway of autophagic mitochondria (Lazarou et al., 2015)