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Cobalt sensitivity reactions can result in different symptoms, such as chronic or subacute allergic contact dermatitis, which can occur immediately or up to 72 hours after administration, but the likelihood of a cobalt allergy is low and affects between 1% and 3% of the general population

& Robinson, S

In fact, by tuning their structure, for example, it is possible to improve the drug functionality thanks to the multivalency effect

CMA is a distinct form of autophagy characterized by its precise targeting and degradation of specific cytosolic proteins

doi: 10.1007/s11154-023-09807-3 137 MehtaKBehlTKumarAUddinMSZenginGAroraS

Thus, dis-inhibition of HKI by consumption of Glc-6-P can stimulate HKI flux by up to 20-fold, a capacity that greatly exceeds the 4-6-fold rise in the cerebral metabolic rate of glucose (CMR glc ) during seizures and ischemia [20, 21]