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Description
Increased serum ALT activity, reflecting ongoing hepatic injury, is reported in 75% to 95% of dogs with chronic hepatitis.4, 7 Serum ALT activity may exceed 10 times the upper normal limit

Am J Physiol 1998;274(5 Pt 2): R1376-R1383
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It plays a vital role in preparing injectable medications
This data was confirmed by BraTS Challenge organizers

However, Skp2 has been identified as E3 ligase for FOXO1, whereas Mdm2 is the prime E3 ligase for p53
